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A novel role for TRPM8 in visceral afferent function

Andrea M Harrington1, Patrick A Hughes, Christopher M Martin

  • 1Nerve-Gut Research Laboratory, Department of Gastroenterology & Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, Australia Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia Discipline of Physiology, University of Adelaide, Adelaide, South Australia, Australia.

Pain
|April 15, 2011
PubMed
Summary

Transient receptor potential ion channel melastatin subtype 8 (TRPM8) is found in colonic sensory neurons. Activating TRPM8 inhibits pain signaling, suggesting a role in managing bowel hypersensitivity.

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