Cervical extramedullary lymphomatoid granulomatosis

Area of Science:

• Oncology
• Neurology
• Pathology

Background:

• Lymphomatoid granulomatosis (LYG) is a rare multisystemic disorder.
• It typically affects the lungs, kidneys, and skin with atypical lymphoid and plasmacytoid cell infiltration.
• Spinal involvement in LYG is exceptionally rare, with limited documented cases.

Observation:

• This case report describes the first instance of cervical extramedullary LYG causing spinal cord compression.
• The patient underwent surgical decompression and partial lesion removal.
• Histopathological diagnosis confirmed grade III LYG.

Findings:

• Post-surgery, the patient showed initial neurological improvement.
• Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) was administered.
• Despite treatment, the patient succumbed to systemic disease progression five months later.

Implications:

• Surgical intervention can be a viable option for managing spinal cord compression in LYG.
• Surgery may alleviate pain and reduce neurological morbidity associated with spinal LYG.
• The overall prognosis for LYG remains guarded, underscoring the need for further research and treatment strategies.