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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Borderline breast lesions: diagnostic challenges and clinical implications.

Shahla Masood1, Marilin Rosa

  • 1Department of Pathology & Laboratory Medicine, College of Medicine, University of Florida, Jacksonville, FL 32209, USA. shahla.masood@jax.ufl.edu

Advances in Anatomic Pathology
|April 15, 2011
PubMed
Summary

Diagnosing challenging breast lesions in small biopsies is difficult. This review clarifies criteria for borderline proliferative breast lesions to improve diagnostic accuracy and consensus.

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Area of Science:

  • Pathology
  • Oncology
  • Radiology

Background:

  • Breast cancer is a global health concern, with advances in imaging improving early detection.
  • Image-guided biopsies increase diagnoses of ductal carcinoma in situ and high-risk proliferative lesions.
  • Pathologists face challenges diagnosing these lesions in small, fragmented biopsy samples.

Purpose of the Study:

  • To review challenging "borderline" proliferative breast lesions.
  • To clarify diagnostic criteria for these lesions.
  • To prompt discussion for achieving diagnostic consensus.

Main Methods:

  • Literature review of diagnostic challenges in breast pathology.
  • Analysis of problematic proliferative breast lesions.
  • Discussion of diagnostic criteria and terminology.

Main Results:

  • Difficulties in differentiating atypical ductal hyperplasia from low-grade ductal carcinoma in situ.
  • Challenges in distinguishing lobular neoplasia from low-grade ductal carcinoma in situ.
  • Complexities in interpreting papillary lesions with atypia and columnar cell changes.

Conclusions:

  • Current diagnostic criteria and terminology for borderline proliferative breast lesions lack consensus.
  • Accurate classification in small biopsies is difficult and carries risks.
  • Further discussion and consensus are needed for improved diagnostic accuracy.