Related Experiment Video
Updated: Jun 2, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
MYC and aggressive B-cell lymphomas
Graham W Slack1, Randy D Gascoyne
1British Columbia Cancer Agency, Vancouver, BC, Canada. gslack@bccancer.bc.ca
Advances in Anatomic Pathology
|April 15, 2011
Summary
MYC gene rearrangements drive aggressive B-cell lymphomas like Burkitt lymphoma. Understanding MYC's role and detection methods is crucial for pathologists diagnosing these cancers.
Area of Science:
- Oncology
- Genetics
- Hematopathology
Background:
- Proto-oncogene MYC deregulation drives oncogenic transformation.
- MYC rearrangement is a key genetic abnormality in aggressive B-cell lymphomas.
Purpose of the Study:
- To review MYC biology and its role in aggressive B-cell lymphomas.
- To explore diagnostic and prognostic implications of MYC rearrangements.
- To outline detection techniques for pathologists.
Main Methods:
- Review of MYC biology and associated lymphomas.
- Analysis of clinical and pathological features.
- Discussion of diagnostic techniques for MYC rearrangement detection.
Main Results:
- MYC rearrangement is recurrent in Burkitt lymphoma, diffuse large B-cell lymphoma, and other aggressive B-cell lymphomas.
- The timing of MYC rearrangement (primary vs. secondary) influences its role in tumorigenesis.
- MYC rearrangement has significant diagnostic and prognostic implications.
Conclusions:
- Familiarity with MYC biology and rearrangement detection is essential for anatomic pathologists.
- Accurate diagnosis of MYC-driven lymphomas impacts patient management and outcomes.
- Understanding MYC deregulation aids in classifying and managing aggressive B-cell lymphomas.
Related Concept Videos
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:06Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:31The Intrinsic Apoptotic Pathway
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
01:24B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...