Factors associated with medication errors in the pediatric emergency department

Mònica Vilà-de-Muga1, Laura Colom-Ferrer, Mariona Gonzàlez-Herrero

  • 1Pediatric Emergency Department, Hospital Universitari Sant Joan de Déu, Barcelona, Spain. mvila@hsjdbcn.es

Insights

Medication errors in pediatric emergency departments occur at a 15% rate, primarily due to incorrect drug indication or dose. Higher error rates are linked to physician experience, weekend/holiday shifts, and nighttime hours.

Area of Science:

  • Pediatric Emergency Medicine
  • Clinical Pharmacy
  • Patient Safety

Background:

  • Medication errors pose a significant risk in pediatric emergency care.
  • Understanding the prevalence and factors contributing to these errors is crucial for improving patient safety.

Purpose of the Study:

  • To determine the frequency, types, and associated factors of medication errors in a pediatric emergency department.

Main Methods:

  • A retrospective descriptive study analyzed treatments in a pediatric emergency department over one week.
  • Errors were classified by type (indication, dose, route), severity, and associated factors (triage, age, physician experience, time).

Main Results:

  • 15% of treatments (92/1906) involved prescription errors, mainly incorrect indication (8%) or dose (7%).
  • Most errors were insignificant; none were severe. Higher error rates occurred with less experienced residents, on weekends/holidays, and during nighttime hours (12 AM - 8 AM).

Conclusions:

  • Medication error rates in emergency departments are comparable to other settings.
  • Increased workload during weekends/holidays and fatigue at night are identified risk factors for prescribing errors.
  • Regular prescription reviews are essential for developing effective error-prevention strategies.
Abstract

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...