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Related Experiment Videos

GAP-43 in the cat visual cortex during postnatal development.

H McIntosh1, N Daw, D Parkinson

  • 1Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.

Visual Neuroscience
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

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Growth associated protein 43 (GAP-43) levels in cat brains decrease with age, correlating with developmental plasticity. Visual deprivation did not affect GAP-43 during the critical period, suggesting its decline indicates remaining plasticity.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Growth associated protein 43 (GAP-43) is implicated in neural plasticity.
  • The critical period for plasticity in the visual cortex is a key developmental stage.
  • Understanding GAP-43's role can illuminate the mechanisms of critical period plasticity.

Purpose of the Study:

  • To investigate the relationship between GAP-43 expression and the duration of the critical period for plasticity in the cat visual cortex.
  • To examine the effect of visual deprivation on GAP-43 levels during postnatal development.
  • To determine if GAP-43 levels can serve as an index of remaining plasticity.

Main Methods:

  • Quantification of GAP-43 levels using immunoassay in cat visual cortex, motor cortex, somatosensory cortex, and cerebellum at various postnatal ages.

Related Experiment Videos

  • Assessment of GAP-43 levels following monocular deprivation for 2-7 days, ending at 27 or 35 days of age.
  • Correlation analysis between membrane-associated GAP-43 concentrations and developmental events.

    • Main Results:

    • GAP-43 levels were high at 5 days old across all brain regions, declining significantly by 60 days and continuing to decrease slowly into adulthood.
    • Monocular deprivation did not alter total membrane GAP-43 levels in the visual cortex.
    • Pre-40 days GAP-43 concentrations correlated with visual cortex development, while the post-40 days decline suggested ongoing plasticity.

    Conclusions:

    • GAP-43 concentrations in the cat visual cortex decrease significantly during postnatal development.
    • Visual deprivation does not affect GAP-43 levels during the critical period, indicating it may not be directly involved in ocular dominance plasticity.
    • The declining levels of membrane-associated GAP-43 after 40 days of age may serve as an indicator of plasticity persistence beyond the critical period's peak.