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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

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Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
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Liver involvement with acute myeloid leukemia.

Emily Mathews1, Timothy Laurie, Kenneth O'Riordan

  • 1Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Ill., USA.

Case Reports in Gastroenterology
|April 15, 2011
PubMed
Summary

Liver involvement in acute myeloid leukemia (AML) is rare. This case highlights AML causing hepatitis-like symptoms, emphasizing the need for low hepatic toxicity treatments for patients with liver involvement.

Keywords:
Acute myeloid leukemiaLiverTransaminitis

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Area of Science:

  • Hematology
  • Hepatology
  • Oncology

Background:

  • Liver involvement in acute myeloid leukemia (AML) is infrequently documented.
  • Published cases typically present with cholestasis and obstructive jaundice.

Observation:

  • This case presented with transaminitis (elevated liver enzymes) without cholestasis.
  • Liver function abnormalities persisted post-cholecystectomy.

Findings:

  • Chemotherapy administration led to the normalization of liver function tests.
  • This suggests that AML was the underlying cause of the hepatitis-like presentation.
  • Literature review indicates poor prognosis and short remissions for AML with liver involvement.

Implications:

  • Patients with AML and liver involvement may benefit from investigational therapies with minimal hepatic toxicity.
  • This case broadens the understanding of AML's potential hepatic manifestations.
  • Highlights the importance of considering AML in unexplained hepatitis-like presentations.