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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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[Calciphylaxis. A call for interdisciplinary cooperation].

V M Brandenburg¹, S Schmitz, J Floege

¹Medizinische Klinik I, Kardiologie, Universitätsklinikum der RWTH Aachen. Vincent.Brandenburg@post.rwth-aachen.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|April 15, 2011

Summary

This summary is machine-generated.

Calciphylaxis is a rare, painful disorder affecting skin due to calcified blood vessels, often seen in dialysis patients. Treatment involves managing mineral metabolism and various therapies, with a new registry aiding research.

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Area of Science:

Nephrology and Dermatology
Vascular Calcification Disorders

Context:

Calciphylaxis is a rare, severe condition causing painful skin lesions and ulcerations.
It is strongly associated with chronic kidney disease and end-stage renal disease requiring dialysis.
Pathophysiology involves calcification and occlusion of cutaneous arterioles, influenced by multiple risk factors.

Purpose:

To summarize the current understanding of calciphylaxis, a complex nephrology-dermatology disorder.
To outline current interdisciplinary treatment strategies based on limited evidence.
To introduce an internet-based registry for collecting data to improve patient care.

Summary:

Calciphylaxis presents with skin necrosis due to calcified, occluded small arteries, predominantly in dialysis patients.
Treatment is multidisciplinary, focusing on mineral metabolism normalization, dialysis optimization, and therapies like calcimimetics and sodium thiosulfate.
An online patient registry has been established to gather crucial data for advancing calciphylaxis management.

Impact:

Highlights the need for improved understanding and management of this life-threatening condition.
The registry aims to facilitate data collection for evidence-based treatment guidelines.
Emphasizes the importance of an interdisciplinary approach for patients with calciphylaxis.