Related Experiment Video
Updated: Jun 2, 2026

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
Published on: November 11, 2025
Continuing challenges in defining image quality
Narendra Shet1, Joseph Chen, Eliot L Siegel
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Abstract:
To achieve significant dose reduction without compromising diagnostic efficacy, it is important to understand the effects of exposure reduction on image quality, a concept that is often mentioned but not well defined in the imaging literature. Studies to assess subjective image quality for digital radiography (DR) demonstrate wide variability among radiologists and technologists, resulting in substantial variability in the determination of acceptable image quality and optimal radiation exposure required to obtain a high-quality radiograph. In addition to improving detector technology and image processing techniques and tailoring exposure to the exam type and patient body habitus, it is possible to take advantage of informatics-based and psychoperceptual approaches. These can be used to establish the relative trade-offs among patient exposure, perceived image quality, and diagnostic efficacy. Innovations such as automated quality assessment of digital radiographs, use of a mathematical model of the human visual system to predict the perceived impact of lower radiation exposure, the creation of a quality-assessment database of images, and better definition and training of radiologists in the determination of image quality can help to reduce variability in assessment and facilitate reductions in dose while minimizing negative effects on image quality.
Related Concept Videos
Quality Assurance
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Phase Contrast and Differential Interference Contrast Microscopy
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
