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Updated: Jun 2, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Electrophile-driven regioselective synthesis of functionalized quinolines

Shaukat Ali1, Hai-Tao Zhu, Xiao-Feng Xia

  • 1State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Chinese Academy of Science, Lanzhou, People's Republic of China.

Organic Letters
|April 16, 2011
PubMed
Summary

A new method synthesizes highly substituted 3-iodoquinolines using 6-endo-dig iodocyclization. This efficient process yields up to 99% and allows for further functionalization of the resulting compounds.

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