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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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Multiple sclerosis in Vest-Agder County, Norway.

A Vatne¹, A Mygland, U Ljøstad

¹Department of Neurology, Sørlandet Hospital, Kristiansand, Norway. anita.vatne@sshf.no

Acta Neurologica Scandinavica

|April 16, 2011

Summary

Multiple sclerosis (MS) prevalence is highest in Vest-Agder, Norway, with a high immunomodulatory treatment rate. Borrelia burgdorferi (Bb) antibodies were not more common in MS patients than in healthy individuals.

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Area of Science:

Neurology
Epidemiology
Infectious Disease

Background:

Multiple sclerosis (MS) is a chronic neurological disease with varying prevalence globally.
Understanding regional variations in MS prevalence and treatment is crucial for public health planning.
The potential role of infectious agents, such as Borrelia burgdorferi (Bb), in MS etiology remains an area of research.

Purpose of the Study:

To determine the prevalence and incidence of MS in Vest-Agder, Norway.
To assess the rate of immunomodulatory treatment among MS patients in the region.
To investigate the frequency of Borrelia burgdorferi (Bb) antibodies in individuals with MS.

Main Methods:

Retrospective study including patients diagnosed with definitive or probable MS between 1996 and 2006.
Data collection included clinical and demographic information and serological testing for Bb antibodies.
Prevalence and incidence rates were calculated and age-adjusted.

Main Results:

A total of 295 MS patients were identified in Vest-Agder.
The age-adjusted MS prevalence was 186 per 100,000 population, the highest reported in Norway.
Immunomodulatory treatment rates were higher in Vest-Agder (38%) compared to the national average (28%).

Conclusions:

Vest-Agder exhibits the highest MS prevalence in Norway, alongside a high rate of immunomodulatory treatment.
The prevalence of Borrelia burgdorferi antibodies in MS patients was similar to that in the general population.
Further research may explore factors contributing to the high MS prevalence in this Norwegian county.