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Related Experiment Videos

Hepatic artery infusion chemotherapy.

A Tuchmann1, J Schüller, A Kroiss

  • 11st Dept. of Surgery, Rudolfstiftung, Vienna, Austria.

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
|March 1, 1990
PubMed
Summary

Hepatic artery chemotherapy using implantable devices showed a 43% response rate in patients with inoperable liver metastases. While complications occurred, treatment offered a mean survival of 13.1 months.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Colorectal cancer frequently metastasizes to the liver, often presenting as inoperable disease.
  • Hepatic artery chemotherapy offers a localized treatment approach for liver metastases.
  • Totally implantable devices facilitate continuous or intermittent chemotherapy delivery.

Purpose of the Study:

  • To evaluate the efficacy and safety of hepatic artery chemotherapy using totally implantable devices for inoperable liver metastases of colorectal origin.
  • To assess treatment response, complications, and survival outcomes.

Main Methods:

  • Thirty-six patients with inoperable liver metastases received hepatic artery chemotherapy via implantable ports and external pumps.
  • Infusion systems were surgically placed into the hepatic artery via the gastroduodenal artery.
  • Fluorodeoxyuridine (FUdR) was infused every two weeks; response was assessed by survival, clinical condition, CEA, ultrasound, and CT.

Main Results:

  • Of 23 evaluable patients, 10 (43%) responded to therapy.
  • Mean survival time was 13.1 months, with a mean interval to relapse of 10.6 months.
  • Minor complications included system thrombosis and port dislodgement; toxic effects were manageable by dose reduction.

Conclusions:

  • Hepatic artery chemotherapy with implantable devices can achieve a response in a significant proportion of patients with inoperable liver metastases.
  • The treatment is associated with manageable toxicity and offers a survival benefit.
  • Further research into optimizing delivery and patient selection is warranted.

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