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Updated: Jun 2, 2026

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
[Acute axonal polyneuropathy and Gougerot-Sjögren syndrome]
N-Y Mapoure1, R Ali-Ahmad, L Aubert
1Service de Neurologie, Hôpital Font-Pré, 1208 avenue Colonel-Picot, 83100 Toulon, France.
Introduction:
Gougerot-Sjögren syndrome (GSS) is an autoimmune disease characterized by a lymphocytic infiltration and destruction of saliva and lachrymal glands. About 20% of patients develop a neurological involvement.
Case Report:
A 29-year-old woman was admitted with a dysautonomic and sensorial neuropathy. Clinical manifestations (dry syndrome and positive Schirmer's test), blood (anti-SSA and anti-SSB antibodies) and histological (chronic sialadenitis) tests linked this neuropathy to a primary GSS. The characteristics of this case were acute onset (within a few days), severe clinical presentation (continued confinement to bed and malnutrition) and non-responsiveness to all treatments (intravenous immunoglobulins, corticosteroids, plasmapheresis, rituximab).
Conclusion:
This case illustrates various clinical signs and inconstant responsiveness to treatment of neuropathy associated with primary GSS.
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