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Updated: Jun 2, 2026
04:04
Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
Lateral temporal bone and parotid malignancy with facial nerve involvement
Avinash V Mantravadi1, Sam J Marzo, John P Leonetti
1Department of Otolaryngology-Head and Neck Surgery, Loyola University of Chicago Stritch School of Medicine, Maywood, IL 60153, USA.
Summary
Surgical treatment for lateral temporal bone (LTB) and parotid malignancy involving the facial nerve (FN) shows favorable outcomes. Advanced age, epithelial tumors, and positive lymph nodes predict poorer survival in these complex cases.
Area of Science:
- Otolaryngology
- Surgical Oncology
- Head and Neck Cancer
Background:
- Malignancies of the lateral temporal bone (LTB) and parotid gland with facial nerve (FN) involvement present complex treatment challenges.
- Accurate prognostic factors and risk assessment are crucial for optimizing patient outcomes in advanced-stage disease.
Purpose of the Study:
- To evaluate the institutional experience and outcomes for LTB and parotid malignancies with FN involvement treated surgically.
- To identify risk factors for treatment failure and clarify prognostic indicators for this patient cohort.
Main Methods:
- Retrospective chart review of 26 patients undergoing operative treatment for LTB and parotid malignancy with FN involvement.
- Analysis of demographic, intraoperative, pathologic, and follow-up data to assess survival and locoregional control.
- Statistical analysis, including Kaplan-Meier and chi-square tests, for risk factor and survival analysis.
Main Results:
- Facial nerve (FN) invasion requiring sacrifice occurred in 57.7% of patients.
- Locoregional recurrence was observed in 34.6% of cases, predominantly within the first two years.
- Overall survival rates at 1, 2, 3, 4, and 5 years were 76.0%, 66.7%, 35.3%, 31.2%, and 28.6%, respectively.
- Advanced age, epithelial tumor origin, and positive lymph nodes were significant predictors of poor survival.
Conclusions:
- Primary surgical treatment for LTB and parotid malignancy with FN involvement yields outcomes comparable to published rates.
- The overall prognosis for this condition may be more favorable than previously established, particularly with appropriate surgical management.
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