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Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.

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Related Experiment Video

Updated: Jun 2, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Tonsillar squamous cell carcinoma: are we making a difference?

Mia E Miller1, David A Elashoff, Elliot Abemayor

  • 1UCLA Medical Center, Los Angeles, California, USA. miaedwards@mednet.ucla.edu

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|April 16, 2011
PubMed
Summary

Outcomes for tonsil squamous cell carcinoma (SCCA) improved from 1998-2006. Survival rates increased with earlier diagnosis and advanced treatments, though non-white ethnicity and older age at diagnosis were linked to higher mortality risks.

Related Experiment Videos

Last Updated: Jun 2, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Area of Science:

  • Oncology
  • Epidemiology
  • Public Health

Background:

  • Squamous cell carcinoma (SCCA) of the tonsil is a significant head and neck cancer.
  • Understanding survival trends and prognostic factors is crucial for improving patient outcomes.
  • Previous studies have explored various aspects of tonsillar SCCA, but long-term population-based survival analyses are essential.

Purpose of the Study:

  • To analyze disease-specific survival outcomes for patients diagnosed with tonsillar squamous cell carcinoma (SCCA) between 1998 and 2006.
  • To identify patient characteristics and treatment modalities that significantly impact disease-specific survival.
  • To assess temporal trends in survival rates for tonsillar SCCA over the study period.

Main Methods:

  • A population-based cohort analysis was conducted using data from the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program.
  • 8378 patients diagnosed with tonsillar SCCA between 1998 and 2006 were included.
  • Univariate and multivariate Cox proportional hazards models were used to correlate survival with sex, age, ethnicity, year of diagnosis, and treatment modality.

Main Results:

  • The cohort comprised 80% males and 85% white patients, with a mean age at diagnosis of 58.1 years.
  • Non-white ethnicity (HR=1.71, P<.001) and each additional year of age at diagnosis (approx. 4% increase in death likelihood) were associated with significantly higher disease-specific death rates.
  • A significant decrease in disease-specific death risk was observed with each passing year of diagnosis (P<.001), with external-beam radiation patients showing improved survival trends over time.

Conclusions:

  • Disease-specific survival for tonsillar squamous cell carcinoma (SCCA) has improved in recent years, as evidenced by population data from the SEER database.
  • Factors contributing to improved survival may include earlier diagnosis, a potential increase in less aggressive SCCA subtypes, and advancements in treatment modalities.
  • Continued monitoring and research are warranted to further optimize treatment strategies and improve survival for tonsillar SCCA patients.