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Updated: Jun 2, 2026
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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Pathways analysis of molecular markers in chronic sinusitis with polyps
Michael P Platt1, Zachary Soler, Ralph Metson
1Department of Otolaryngology-Head and Neck Surgery, Boston University, Boston, Massachusetts 02118, USA. Michael.platt@bmc.org
Summary
Chronic sinusitis with polyps involves complex molecular pathways. Pathway analysis of candidate genes identified key mediators, suggesting potential new therapeutic targets for this condition.
Area of Science:
- Genomics and Molecular Biology
- Immunology
- Otolaryngology
Background:
- Chronic sinusitis with polyps (CRSwP) is a complex inflammatory upper airway disease.
- Multiple genetic and environmental factors are suspected contributors to CRSwP pathogenesis.
- Numerous candidate genes have been identified through various molecular studies.
Purpose of the Study:
- To conduct a comprehensive molecular pathways analysis of genes associated with CRSwP.
- To identify central molecules and pathways implicated in the disease's pathogenesis.
- To compare pathways identified from literature review with those from genome-wide expression profiling.
Main Methods:
- Molecular pathways analysis using Ingenuity Pathways Analysis software.
- Analysis of genes from PubMed literature search and genome-wide expression profiling of ethmoid polyps.
- Investigation of 97 molecules from 55 studies encompassing gene expression, genetic variation, and proteomics.
Main Results:
- Identification of 9 statistically significant molecular networks with key nodes including transcription factors, kinases, cytokines, and growth factors.
- The highest scoring networks implicated nuclear factor kappa-B, tumor necrosis factor, and mitogen-activated protein kinases.
- Significant overlap was observed between pathways identified from literature analysis and genome-wide expression data.
Conclusions:
- CRSwP is a multifactorial disease with identified candidate genes.
- Pathway analysis revealed common central molecules crucial for disease mediation.
- Targeting these identified molecules may offer novel therapeutic strategies for CRSwP.
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