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Updated: Jun 2, 2026
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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
Eosinophilic allergic polyp: a clinically oriented concept of nasal polyp
Woo-Jin Jeong1, Chul Hee Lee, Sang-Heon Cho
1Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.
Summary
A new definition for eosinophilic allergic polyp (EAP) is proposed, using a tissue eosinophil count of 11% or more. This criterion helps identify nasal polyps associated with allergy and asthma.
Area of Science:
- Otorhinolaryngology
- Allergy and Immunology
- Pathology
Background:
- Tissue eosinophilia is characteristic of nasal polyposis.
- A standardized definition for eosinophilic nasal polyps is lacking.
- This study aims to define eosinophilic allergic polyp (EAP) for clinical utility.
Purpose of the Study:
- To histologically analyze inflammatory cell populations in nasal polyps.
- To propose a simple, objective definition for EAP.
- To establish a clinically valuable concept for EAP.
Main Methods:
- A cohort study involving histological analysis of 118 nasal polyp tissue samples.
- Inflammatory cell counts, including eosinophils, were performed.
- Receiver operating characteristic curve analysis identified the optimal eosinophil cutoff for EAP.
Main Results:
- Eosinophils constituted an average of 18.7% of inflammatory cells in nasal polyps.
- 90.7% of polyps showed some eosinophil infiltration.
- An eosinophil proportion of 11% was identified as significant for EAP, present in 62.7% of cases.
Conclusions:
- A tissue eosinophil proportion exceeding 11% is proposed as the criterion for EAP.
- This definition of EAP correlates well with clinical indicators of asthma and allergy.
- The proposed EAP definition offers practical clinical value.
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