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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Natural evolution of Spitz nevi.

Giuseppe Argenziano1, Marina Agozzino, Ernesto Bonifazi

  • 1Dermatology Unit, 1st Medical Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. g.argenziano@gmail.com

Dermatology (Basel, Switzerland)
|April 16, 2011
PubMed
Summary

Spitz nevi commonly undergo spontaneous involution, with most lesions showing regression over time. Growing Spitz nevi are typically pigmented, while involuting lesions are often amelanotic.

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Area of Science:

  • Dermatology
  • Pathology
  • Oncology

Background:

  • Melanocytic nevi evolution is complex and multifactorial.
  • Long-term monitoring aids in studying nevus natural history.
  • Spitz nevi require careful evaluation due to potential melanoma association.

Purpose of the Study:

  • To investigate the natural evolution pathway of Spitz nevi.
  • To determine the common biologic behavior of Spitz nevi.
  • To identify clinical and dermoscopic predictors of Spitz nevus evolution.

Main Methods:

  • Prospective monitoring of lesions with Spitz nevus features.
  • Comparison of baseline and follow-up dermoscopic images.
  • Statistical analysis of lesion characteristics and evolution patterns.

Main Results:

  • 64 patients with suspected Spitz nevi were followed for a mean of 25 months.
  • 79.7% of Spitz nevi exhibited involution, while 20.3% showed growth or stability.
  • Pigmentation was more common in growing lesions (92.3%), whereas amelanosis was frequent in involuting lesions (47.1%).

Conclusions:

  • Spontaneous involution is the predominant behavior of Spitz nevi.
  • Clinical and dermoscopic features may indicate different evolutionary trajectories.
  • Further research is needed to fully elucidate Spitz nevus behavior.