Related Experiment Video
Updated: Jun 2, 2026
Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology
Published on: July 12, 2022
Do resin cements alter action potentials of isolated rat sciatic nerve?
Ahmet Atila Ertan1, Nilufer Celebi Beriat, Mehmet Ali Onur
1Hacettepe University, Faculty of Dentistry, Department of Prosthodontics, Ankara, Turkey.
Objectives:
The purpose of this study was to explore the effects dual-cure resin cements on nerve conduction.
Methods:
Panavia F, RelyX ARC, and Variolink II polymerized either by light-emitting diode (LED) or quartz tungsten halogen (QTH) were used in the study (n=10). The conductance of sciatic nerves of 50 rats were measured before and after contact with the specimens for 1 h.
Results:
The time-dependent change in nerve conductance and the comparison of LED versus QTH showed that differences between groups are significant (P<.05). For both polymerization techniques, pair-wise comparisons of resin cements showed that the nerve conductance between groups is different (P<.05). RelyX ARC elicited irreversible inhibition of compound action potentials (more than 50% change) and Panavia F and Variolink II polymerized by LED and QTH did not alter nerve conduction beyond physiologic limits.
Conclusions:
Resin cements may alter nerve conductance and even lead to neurotoxic effects.
