Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

Schizophrenia

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The 'hub' model for colorectal surgery: a viable paradigm shift?

Annals of the Royal College of Surgeons of England·2025

Same author

Cough-induced vertebral artery dissection: A case report and literature review.

The journal of the Royal College of Physicians of Edinburgh·2024

Same author

Selecting laser-resistant tracheal tubes for awake flexible scope intubation.

Anaesthesia reports·2024

Same author

Level of polychlorinated biphenyls in tumor and blood serum of breast cancer patients and control subjects from Punjab, Pakistan.

The Science of the total environment·2024

Same author

Fabricating a 3D floating porous PDMS - Ag/AgBr decorated g-C<sub>3</sub>N<sub>4</sub> nanocomposite sponge as a re-usable visible light photocatalyst.

Scientific reports·2024

Same author

Corrigendum to "The collapsed newborn in the emergency department" [<i>BJA Education</i> 18 (2018) 254-8].

BJA education·2024

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Neurological soft signs, cognitive dysfunction and ventricular brain ration in schizophrenics.

N Lal¹, S C Tiwari, S Srivastava

¹M.D., Professor, Department of Psychiatry, K.G. Medical College, Lucknow.

Indian Journal of Psychiatry

|April 16, 2011

Summary

Schizophrenia subtypes differ in cognitive function and neurological signs. Positive schizophrenia subtypes show better cognitive performance and distinct correlations with brain structure compared to negative subtypes.

Keywords:

Schizophrenia negative subtype neurological soft signs neuropsychological tests positive subtype ventricular brain ratio

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Related Experiment Videos

Last Updated: Jun 2, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Schizophrenia is linked to cognitive deficits, neurological soft signs, and brain structure changes like enlarged ventricles and widened sulci.
The positive and negative symptom dichotomy in schizophrenia may relate to distinct clinical and neurobiological profiles.

Purpose of the Study:

To investigate the relationship between the positive/negative symptom dichotomy in schizophrenia.
To assess its impact on neuropsychological performance.
To examine the presence of neurological soft signs in relation to these subtypes.

Main Methods:

Studied 23 schizophrenia patients diagnosed using DSM-III-R criteria.
Classified patients into positive (14) and negative (9) subtypes.
Assessed neuropsychological performance (WMS, IQ, BGT) and neurological soft signs.
Measured Ventricular Brain Ratio (VBR) as an indicator of brain structure.

Main Results:

All patients exhibited at least one neurological soft sign.
The positive subtype group scored higher on Wechsler Memory Scale (WMS) and IQ tests.
The positive subtype group scored lower on the Boston Naming Test (BGT).
WMS and BGT scores showed a negative correlation with Ventricular Brain Ratio (VBR).
Neurological soft signs positively correlated with VBR in the positive subtype only.

Conclusions:

The positive and negative symptom dimensions in schizophrenia are associated with differential neuropsychological profiles.
Brain structural changes (VBR) and neurological soft signs show distinct relationships with these symptom dimensions.