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Related Concept Videos

Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

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Related Experiment Video

Updated: Jun 2, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Risperidone in Indian patients with schizophrenia.

A K Agarwal1, V S Bashyam, S M Channabasavanna

  • 1AGARWAL, A.K., M.D., D.P.M., Professor & Head, Department of Psychiatry, King George's Medical College, Lucknow.

Indian Journal of Psychiatry
|April 16, 2011
PubMed
Summary
This summary is machine-generated.

Risperidone effectively treated schizophrenia symptoms in Indian patients, showing significant improvement in positive, negative, and general psychopathology. This novel antipsychotic demonstrated efficacy with manageable side effects.

Keywords:
Indian patientsPANSSRisperidoneclinical improvementnovel antipsychotic agentsschizophrenia

Related Experiment Videos

Last Updated: Jun 2, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Area of Science:

  • Psychiatry and Pharmacology
  • Neuroscience

Background:

  • Conventional antipsychotics are ineffective for negative schizophrenia symptoms and cause extrapyramidal side effects.
  • Risperidone, a novel agent, targets dopamine and serotonin receptors, suggesting potential efficacy for negative symptoms and fewer side effects.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of risperidone in treating schizophrenia among Indian patients.
  • To assess risperidone's impact on negative symptoms, positive symptoms, general psychopathology, and overall severity.

Main Methods:

  • An open, non-comparative, seven-week study.
  • 146 evaluable Indian patients with schizophrenia participated.
  • Patients transitioned from previous antipsychotics to risperidone after a one-week washout period.

Main Results:

  • 87.7% of patients (128/146) showed clinical improvement (≥20% PANSS score reduction) after six weeks.
  • Statistically significant reductions were observed in PANSS total scores, positive, negative, and general psychopathology subscales.
  • Adverse experiences increased slightly, with mild to moderate extrapyramidal symptoms reported in 39.4% of patients.

Conclusions:

  • Risperidone demonstrates significant efficacy in treating schizophrenia, including negative symptoms, in the Indian population.
  • The drug is generally well-tolerated, though extrapyramidal symptoms require monitoring.
  • Risperidone represents a valuable therapeutic option for schizophrenia management.