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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Published on: June 2, 2014

Migraine increases centre-surround suppression for drifting visual stimuli.

Josephine Battista1, David R Badcock, Allison M McKendrick

  • 1Department of Optometry & Vision Sciences, The University of Melbourne, Parkville, Australia.

Plos One
|April 16, 2011
PubMed
Summary
This summary is machine-generated.

Migraine patients exhibit heightened visual surround suppression for drifting stimuli, suggesting an imbalance in cortical excitation and inhibition. This finding challenges simple models of reduced inhibition in migraine pathophysiology.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Perception

Background:

  • Migraine pathophysiology involves cortical neuron hyper-responsivity.
  • The basis of this hyper-responsivity, whether reduced inhibition or increased excitation, is unclear.
  • Cortical visual processing involves interplay between inhibition and excitation.

Purpose of the Study:

  • To investigate visual surround suppression in people with migraine.
  • To use perceptual measures as an analogue for cortical inhibition-excitation balance.
  • To test the hypothesis that reduced inhibition in migraine decreases perceptual surround suppression.

Main Methods:

  • Measured center-surround contrast suppression in 26 migraine patients and 20 controls.
  • Utilized static and drifting sinusoidal gratings at varying contrasts.
  • Assessed perceived contrast of a central patch with and without an annular grating surround.

Main Results:

  • No significant difference in surround suppression for static gratings between groups.
  • Migraine group showed significantly increased surround suppression for drifting stimuli (p<0.01).
  • Perceived contrast was 53% of actual for migraineurs vs. 68% for controls with drifting stimuli.

Conclusions:

  • Asymptomatic individuals with migraine display enhanced visual surround suppression for drifting stimuli.
  • Results indicate a measurable imbalance in visual inhibitory and excitatory processes in migraine.
  • Findings contradict models solely based on reduced cortical inhibitory function in migraine.