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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Related Experiment Videos

[Nutritional guidelines and standards in geriatrics].

D Volkert1

  • 1Institut für Biomedizin des Alterns, Friedrich-Alexander-Universität Erlangen-Nürnberg, Heimerichstr. 58, 90419, Nürnberg, Deutschland. dorothee.volkert@aging.med.uni-erlangen.de

Zeitschrift Fur Gerontologie Und Geriatrie
|April 16, 2011
PubMed
Summary
This summary is machine-generated.

Nutritional deficiencies are common in elderly care facilities. Implementing evidence-based guidelines for nutritional care is crucial for improving the health of institutionalized older adults.

Related Experiment Videos

Area of Science:

  • Geriatric Medicine
  • Nutrition Science
  • Healthcare Management

Context:

  • Widespread nutritional problems and deficiencies in geriatric institutions.
  • Established benefits of various interventions for elderly nutrition.
  • Need for practical application of scientific knowledge.

Purpose:

  • To highlight the importance of evidence-based guidelines for nutritional care in elderly institutions.
  • To emphasize the role of standards in translating research into practice.
  • To advocate for the routine implementation of these guidelines.

Summary:

  • Several guidelines and standards exist, including the Medical Guidelines for Enteral and Parenteral Nutrition in Geriatrics (DGEM/DGG and ESPEN), DNQP Expert Standard, DGE Quality Standards, and BUKO-QS Standard.
  • These provide recommendations for adequate nutritional care for institutionalized elderly individuals.
  • They serve as a basis for developing local protocols to manage nutritional issues and malnutrition.

Impact:

  • Ensuring elderly residents receive optimal nutritional support.
  • Improving the overall health and well-being of institutionalized older adults.
  • Facilitating the consistent application of best practices in geriatric nutrition.