Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
Biosynthesis in Bacteria01:24

Biosynthesis in Bacteria

Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which provide...
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Enzymes02:34

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SAM-dependent methyltransferases: from chemoenzymatic natural product synthesis to industrial application.

Natural product reports·2026
Same author

Stereoselective Prenylation of Aryl- and Heteroaryl Halides: γ-Selective Suzuki-Miyaura Coupling as a Tool for Asymmetric Csp<sup>2</sup>-Csp<sup>3</sup> Cross-Coupling.

The Journal of organic chemistry·2026
Same author

Characterisation of the N-Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines.

Angewandte Chemie (International ed. in English)·2025
Same author

Influence of ionic liquids on enzymatic asymmetric carboligations.

Computational and structural biotechnology journal·2025
Same author

Resolution of physics and deep learning-based protein engineering filters: A case study with a lipase for industrial substrate hydrolysis.

PloS one·2025
Same author

Re-engineering a transferase scaffold for indole C3 methylation in diketopiperazines.

Protein science : a publication of the Protein Society·2025

Related Experiment Video

Updated: Jun 2, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Key building blocks via enzyme-mediated synthesis.

Thomas Fischer1, Jörg Pietruszka

  • 1Institut für Bioorganische Chemie der Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Stettemicher Forst Geb. 15.8, 52426 Jülich, Germany.

Topics in Current Chemistry
|April 16, 2011
PubMed
Summary

Enzymatic conversions offer eco-friendly and efficient methods for synthesizing valuable compounds in organic synthesis. This review highlights established biocatalytic systems and recent advances, focusing on enzymes used in natural product synthesis.

More Related Videos

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments
20:28

A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments

Published on: October 2, 2012

Related Experiment Videos

Last Updated: Jun 2, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments
20:28

A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments

Published on: October 2, 2012

Area of Science:

  • Organic Chemistry
  • Biotechnology
  • Enzymology

Background:

  • Biocatalysis has become a key strategy in organic synthesis, expanding beyond hydrolases to include oxidoreductases and lyases.
  • Enzymatic biotransformations are increasingly utilized in the chemical and pharmaceutical industries for producing fine chemicals and drugs.

Purpose of the Study:

  • To provide insights into established biocatalytic systems and recent advancements in enzyme applications for natural product synthesis.
  • To focus on frequently used enzymes or enzyme classes not covered in other related volumes.

Main Methods:

  • Review of literature on biocatalytic approaches in organic synthesis.
  • Focus on enzyme classes like oxidoreductases and lyases.
  • Analysis of applications in natural product synthesis.

Main Results:

  • Biocatalysis offers mild reaction conditions, high selectivity (stereo-, regio-, chemo-), and shorter pathways.
  • Enzymatic conversions present significant economic and ecological advantages.
  • A wide array of biotransformations are applicable in industrial settings.

Conclusions:

  • Enzymatic synthesis is a powerful and sustainable tool for creating complex molecules.
  • Continued research into diverse enzyme classes will further expand biocatalysis applications.
  • Biocatalysis plays a crucial role in the efficient and green production of pharmaceuticals and fine chemicals.