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[Hyperhomocysteinemia, risk factor in deep venous thrombosis: a case-control study]
Cristina Hoţoleanu1, Maria Dronca, Eleonora Dronca
1Universitatea de Medicină şi Farmacie I. Haţieganu Cluj-Napoca, Facultatea de Medicină, Clinica a II(-a) Medicală.
Summary
Hyperhomocysteinemia is an independent risk factor for deep venous thrombosis (DVT). This study found a weak but significant association, highlighting its importance in DVT development.
Area of Science:
- Cardiovascular Medicine
- Hematology
Background:
- Hyperhomocysteinemia is a known cardiovascular risk factor.
- Recent research suggests a link between hyperhomocysteinemia and deep venous thrombosis (DVT).
Purpose of the Study:
- To investigate the association between hyperhomocysteinemia and DVT.
- To identify other acquired risk factors for DVT.
Main Methods:
- A matched case-control study involving 127 DVT patients and 100 controls.
- Homocysteinemia levels were measured using reverse-phase high-performance liquid chromatography.
- Doppler ultrasonography confirmed DVT diagnosis.
Main Results:
- A significant association was found between hyperhomocysteinemia and DVT (OR: 1.7, p=0.025).
- Other independent risk factors for DVT included obesity, varicose veins, prolonged immobility, and a history of DVT.
- Multivariate logistic regression confirmed these as independent risk factors.
Conclusions:
- Hyperhomocysteinemia is an independent risk factor for DVT.
- The risk of DVT associated with hyperhomocysteinemia is not dependent on its severity.
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