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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
Published on: February 23, 2020
Pulmonary function is associated with distal aortic calcium, not proximal aortic distensibility. MESA lung study
David A McAllister1, William MacNee, Daniel Duprez
1MRC/ELEGI Colt Laboratories, University of Edinburgh, Edinburgh, UK.
COPD
|April 19, 2011
Summary
Forced expiratory volume in one second (FEV(1)) predicts cardiovascular mortality and is linked to distal aortic calcification. This study found FEV(1) associated with abdominal aortic calcification, but not proximal aorta stiffness.
Area of Science:
- Cardiovascular Medicine
- Pulmonology
- Radiology
Background:
- Forced expiratory volume in one second (FEV(1)) is a strong predictor of cardiovascular disease mortality.
- Aortic stiffness is an independent predictor of cardiovascular mortality.
- The relationship between lung function and aortic stiffness, specifically the anatomical site and mechanisms, remains unclear.
Purpose of the Study:
- To investigate the association between FEV(1) and CT-measured percent emphysema with abdominal aortic calcification and proximal thoracic aortic distensibility.
- To explore potential links between lung function and vascular health.
Main Methods:
- Utilized data from the Multi-Ethnic Study of Atherosclerosis (MESA).
- Measured aortic calcification via CT scans and proximal aortic distensibility using MRI.
- Assessed lung function with spirometry and percent emphysema from CT scans.
- Performed multivariate analyses adjusting for age, sex, race/ethnicity, and cardiovascular risk factors.
Main Results:
- FEV(1) was significantly associated with the extent of distal (abdominal) aortic calcification (p = 0.02).
- No significant association was found between FEV(1) and proximal aortic calcification or distensibility (p = 0.60).
- Percent emphysema showed no association with either abdominal or proximal aortic measures.
Conclusions:
- FEV(1) is associated with distal aortic calcification, independent of smoking and cardiovascular risk factors.
- Lung function, specifically FEV(1), may play a role in the development of abdominal aortic calcification.
- The association does not extend to proximal aortic stiffness or calcification.
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