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Clinical aspects of the early repolarization syndrome: a 2011 update

Shlomo Stern1

  • 1Hebrew University of Jerusalem, Israel. sh_stern@netvision.net.il

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|April 19, 2011
PubMed

Insights

Early repolarization syndrome, characterized by J-point ST-elevation on ECG, may indicate a risk for ventricular fibrillation. However, it is not considered a high-risk marker in the general population, though further research is needed.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Early repolarization syndrome (ERS) is an electrocardiographic (ECG) finding.
  • Historically considered benign, recent studies question its safety.

Purpose of the Study:

  • To evaluate the clinical significance of J-point ST-elevation in early repolarization syndrome.
  • To determine if ERS is a risk factor for sudden cardiac death.

Main Methods:

  • Review of recent studies (2008/2009) on ERS and J-point ST-elevation.
  • Analysis of retrospective data regarding inferolateral leads ECG findings.

Main Results:

  • ERS may be associated with an increased risk of ventricular fibrillation.
  • Risk appears minimal in athletes and not significant in the general population.
  • Association with Brugada syndrome remains unproven.

Conclusions:

  • ERS warrants careful evaluation in specific patient groups (syncope, arrhythmias, family history).
  • It is not currently considered a high-risk marker for sudden cardiac death in the general population.
  • Further prospective and genetic studies are required to clarify ERS's clinical significance.

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