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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
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Gene silencing in HIV-1 latency by polycomb repressive group

Hyeon Guk Kim1, Kyung-Chang Kim, Tae-Young Roh

  • 1Division of AIDS, Center for Immunology and Pathology, Korea National Institute of Health, Chung-buk, Republic of Korea.

Virology Journal
|April 19, 2011
PubMed
Summary

Epigenetic modifications, including histone H3K27 trimethylation and H2A ubiquitylation, are implicated in human immunodeficiency virus-1 (HIV-1) latency. These changes in NCHA cells suggest a role for polycomb group proteins in HIV-1 persistence.

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