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Hemiballismus.

Francisco Grandas1

  • 1Department of Neurology, Hospital Universitario Gregorio Marañón and Parkinson's Disease and Movement Disorders Unit, Hospital Beata Maria Ana, Madrid, Spain. fgrandasp@meditex.es

Handbook of Clinical Neurology
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Hemiballism, a rare movement disorder, involves involuntary limb movements. While often linked to the subthalamic nucleus, lesions in other basal ganglia structures are common, and prognosis is generally good.

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Area of Science:

  • Neurology
  • Movement Disorders

Background:

  • Hemiballism is a rare hyperkinetic movement disorder causing involuntary, violent limb movements.
  • Classically associated with subthalamic nucleus lesions, most cases involve other basal ganglia structures.
  • Pathogenesis may involve abnormal neuronal firing in the globus pallidus.

Purpose of the Study:

  • To review the clinical-radiological features, causes, prognosis, and treatment of hemiballism.
  • To highlight the evolving understanding of hemiballism's underlying pathology and common causes.

Main Methods:

  • Review of clinical-radiological series of hemiballism patients.
  • Analysis of reported cases associated with stroke, nonketotic hyperglycemia, and HIV infection.

Main Results:

  • Most hemiballism cases have lesions outside the subthalamic nucleus, primarily in other basal ganglia.
  • Stroke is the most frequent cause, with increasing reports linked to nonketotic hyperglycemia and HIV.
  • Hemiballism generally has a good prognosis with potential for spontaneous improvement.

Conclusions:

  • Hemiballism etiology is diverse, extending beyond the subthalamic nucleus.
  • Prompt diagnosis and cause-directed treatment, alongside symptomatic therapies like dopamine receptor blockers or tetrabenazine, are crucial.
  • Surgical options like pallidotomy exist for severe, persistent cases.