Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

24.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.6K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biosynthetic gene clusters in <i>Pseudomonas viridiflava</i> have a fitness cost during <i>Arabidopsis thaliana</i> infection.

mSystems·2026
Same author

Seasonality, land use and plant community diversity shape microbiome-pathogen interactions in wild populations of Arabidopsis thaliana.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

PLANeT: Understanding and leveraging the genome of land plants for a sustainable future.

Cell·2026
Same author

Rapid adaptation and extinction in synchronized outdoor evolution experiments of <i>Arabidopsis</i>.

Science (New York, N.Y.)·2026
Same author

Multiple redundant mechanisms account for the majority of gene silencing downstream of DNA methylation.

bioRxiv : the preprint server for biology·2026
Same author

Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.

Genetics·2026

Related Experiment Video

Updated: Jan 29, 2026

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
07:01

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

1.9K

Argonaute10 as a miRNA locker.

Pablo A Manavella1, Detlef Weigel, Liang Wu

  • 1Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany.

Cell
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Plants use Argonaute proteins to sequester microRNAs (miRNAs), preventing them from regulating messenger RNA stability and translation. This study reveals a novel regulatory mechanism in plants involving miRNA-Argonaute binding.

More Related Videos

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

2.9K
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
08:41

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats

Published on: July 19, 2013

13.1K

Related Experiment Videos

Last Updated: Jan 29, 2026

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
07:01

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

1.9K
mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

2.9K
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
08:41

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats

Published on: July 19, 2013

13.1K

Area of Science:

  • Molecular Biology
  • Plant Science
  • Gene Regulation

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, influencing messenger RNA (mRNA) stability and translation efficiency.
  • Argonaute (AGO) proteins are essential components of the RNA-induced silencing complex (RISC), mediating miRNA function.
  • Understanding miRNA-mediated gene regulation is crucial for plant development and stress responses.

Discussion:

  • Zhu, Zhang, and colleagues demonstrate that Argonaute proteins in plants can act as a sequestration mechanism for miRNAs.
  • This binding prevents miRNAs from engaging with their target mRNAs, thereby inhibiting their regulatory functions.
  • This finding reveals a novel layer of post-transcriptional gene regulation in plants.

Key Insights:

  • Plant Argonaute proteins can sequester miRNAs, limiting their availability for target recognition.
  • This sequestration mechanism provides an additional layer of control over gene expression.
  • The study highlights the diverse roles of Argonaute proteins in plant miRNA pathways.

Outlook:

  • Further research is needed to elucidate the specific conditions and factors that trigger miRNA sequestration by Argonaute proteins.
  • Investigating the evolutionary conservation of this mechanism across different plant species will be important.
  • This discovery opens new avenues for understanding plant gene regulation and developing strategies for crop improvement.