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Related Experiment Video

Updated: Jun 2, 2026

Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Single-lung transplantation: does side matter?

Sokratis Tsagkaropoulos1, Ann Belmans, Geert M Verleden

  • 1Department of Thoracic Surgery, University La Sapienza Rome, Rome, Italy.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

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Single-lung transplantation (SLTx) outcomes are similar regardless of whether the left or right lung is transplanted. Transplant side does not impact survival, complications, or pulmonary function, offering flexibility in donor lung allocation.

Area of Science:

  • Thoracic Surgery
  • Pulmonary Medicine
  • Transplantation Immunology

Background:

  • Single-lung transplantation (SLTx) is a critical treatment for end-stage pulmonary disease, helping to address organ shortages.
  • Lung side selection for SLTx is typically based on perfusion scans, but the impact of left versus right SLTx on outcomes is not well understood.

Purpose of the Study:

  • To compare the outcomes of left (L) versus right (R) single-lung transplantation.
  • To determine if the side of lung transplantation influences patient survival, pulmonary function, or complication rates.

Main Methods:

  • A retrospective analysis of 142 first single-lung transplantations performed between July 1991 and July 2009.
  • Comparison of donor and recipient characteristics, early outcomes (e.g., bypass, extubation time, ICU/hospital stay, 30-day mortality), and late outcomes (survival, FEV1, complications, bronchiolitis obliterans syndrome (BOS)) between left and right SLTx recipients.

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Last Updated: Jun 2, 2026

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Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
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Main Results:

  • No significant differences were observed in overall survival, 30-day mortality, ICU/hospital stay, or time to extubation between L-SLTx and R-SLTx.
  • Pulmonary function (FEV1) improved comparably in both groups. Complication rates and freedom from BOS were similar across both sides.
  • While donor age differed (younger for L-SLTx), and recipient indications varied (more emphysema in R-SLTx), multivariate analysis showed neither side nor perfusion mismatch significantly impacted survival, though BOS was a negative predictor.

Conclusions:

  • The side chosen for single-lung transplantation does not affect recipient survival, pulmonary function, or complication rates.
  • Transplant side preference may differ based on recipient diagnosis (emphysema vs. fibrosis).
  • Donor lung offers for the non-preferred side should not be rejected solely based on side, considering the comparable outcomes.