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Updated: Jun 2, 2026

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Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
Three-dimensional quantification of mandibular asymmetry through cone-beam computerized tomography
Lucia H S Cevidanes1, Abeer Alhadidi, Beatriz Paniagua
1Department of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA. cevidanl@dentistry.unc.edu
Summary
Three-dimensional (3D) shape analysis accurately quantifies mandibular asymmetry. Both midsagittal plane mirroring and cranial base registration methods precisely diagnose differences in patients with asymmetry.
Area of Science:
- Dental imaging and analysis
- Biomechanical and biomaterial engineering
- Medical diagnostics
Background:
- Mandibular asymmetry presents a significant clinical challenge.
- Accurate diagnosis and quantification are crucial for effective treatment planning.
- Existing methods may have limitations in precision and applicability.
Purpose of the Study:
- To evaluate the precision of 3D shape analysis in diagnosing right and left mandibular asymmetry.
- To compare two distinct mirroring approaches for quantifying asymmetry.
Main Methods:
- Cone-beam computed tomography (CT) data from 20 patients with mandibular asymmetry were analyzed.
- Two 3D shape analysis methods were employed: midsagittal plane mirroring and cranial base registration.
- Validation involved simulated data and application to three clinical cases.
Main Results:
- Midsagittal plane mirroring demonstrated >99% probability of asymmetry measurement differences <0.5 mm.
- Cranial base registration showed >84% probability of asymmetry measurement differences <0.5 mm.
- Both methods proved highly precise in quantifying simulated asymmetry.
Conclusions:
- 3D shape analysis provides precise quantification of mandibular asymmetry.
- Cranial base registration offers a valuable alternative when landmarks are unreliable or absent, such as in trauma cases.
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