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Updated: Jun 2, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica
Emma Maldonado1, Ana L Pérez-Castorena, Consuelo Garcés
1Instituto de Química, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510, D. F., Mexico. emmaldon@unam.mx
Abstract:
Two new withanolides, philadelphicalactone C (1) and philadelphicalactone D (4), along with the known withaphysacarpin (3), ixocarpanolide (5), philadelphicalactone A (6), and ixocarpalactone A (7) were isolated from the aerial parts of Physalis philadelphica Lam. Structures of these compounds were determined by spectroscopic analyses and that of philadelphicalactone C (1) was confirmed by X-ray crystallographic analysis. Evaluation of the cytotoxic activity of all isolates and the derivative 2 against a panel of human cancer cell lines indicated a potent activity of compounds 2, 3, 6, and 7.
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