Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Investigator-Led Research to Improve the Diagnostic Assessment of Platelet Function Disorders: Reflections on the Challenges and Rewards.

International journal of laboratory hematology·2026

Same author

When it's not Glanzmann thrombasthenia or Bernard-Soulier syndrome: diagnosing other qualitative platelet disorders.

Hematology. American Society of Hematology. Education Program·2025

Same author

Laboratory diagnosis of congenital and acquired coagulopathies, including challenging-to-diagnose rare bleeding disorders.

Pathology·2025

Same author

How Trustworthy is Light Transmittance Platelet Aggregometry With Low Platelet Count Samples? Insights From Test Replicates and Retrospective Analysis of Several Decades of Diagnostic Samples.

International journal of laboratory hematology·2025

Same author

Case Report: Tranexamic Acid Therapy Corrects the Impaired Epinephrine Aggregation Responses of Quebec Platelet Disorder.

International journal of laboratory hematology·2025

Same author

Vitamin K Deficiency: Diagnosis and Management.

Annals of laboratory medicine·2025

Same journal

Treating large B-cell lymphoma: Current strategies and unmet needs across community and academic settings.

Blood reviews·2026

Same journal

MRD in multiple myeloma: Moving from "minimal" to "measurable".

Blood reviews·2026

Same journal

PRISMA-based systematic review on iron stores in repeat blood donors.

Blood reviews·2026

Same journal

Artificial intelligence applications in thrombotic thrombocytopenic Purpura: A systematic review of diagnostic, risk stratification, and prognostic models.

Blood reviews·2026

Same journal

Antibacterial, antifungal and antiviral prophylaxis and vaccination strategies in adult patients with acute myeloid and promyelocytic leukemia: An expert panel consensus from the GIMEMA group.

Blood reviews·2026

Same journal

The Lebanese national patient blood management guidelines: A new page in the medical practice.

Blood reviews·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Diagnostic evaluation of platelet function disorders.

Catherine P M Hayward¹

¹Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. haywrdc@mcmaster.ca

|April 19, 2011

Summary

This summary is machine-generated.

Diagnosing platelet function disorders is challenging due to varied symptoms and diagnostic methods. Standardized lab tests are crucial for identifying these common bleeding conditions.

More Related Videos

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Related Experiment Videos

Last Updated: Jun 2, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Area of Science:

Hematology
Clinical Diagnostics

Background:

Platelet function disorders (PFDs) are a frequent cause of bleeding, often presenting similarly to von Willebrand disease.
Diagnosing PFDs is complex due to heterogeneous clinical features, unclear pathogenesis, and variable laboratory procedures.
Existing bleeding assessment tools lack validation for diagnosing PFDs.

Purpose of the Study:

To highlight the challenges in diagnosing platelet function disorders.
To emphasize the importance of standardized laboratory testing for PFD diagnosis.
To identify areas needing further research in PFDs.

Main Methods:

Review of existing literature on platelet function disorders.
Analysis of diagnostic challenges and current laboratory practices.
Evaluation of standardized tests for platelet aggregation, dense granule deficiency, and secretion.

Main Results:

Standardized tests for aggregation, dense granule deficiency, and secretion aid in diagnosing common and rare PFDs.
Emerging guidelines aim to standardize laboratory tests and aggregometry interpretation for PFDs.
Despite progress, many PFDs, especially those affecting granule secretion, require further investigation into features, pathogenesis, and genetics.

Conclusions:

Standardized laboratory testing is essential for diagnosing platelet function disorders.
Further research is needed to elucidate the features, pathogenesis, and genetic underpinnings of many PFDs.
Guidelines for laboratory testing and interpretation are improving PFD diagnosis.