Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alternative models of consent in out-of-hospital transfusion trials: a CAN-PATT position statement supporting exception from prospective consent with opt-out notification.

Scandinavian journal of trauma, resuscitation and emergency medicine·2026
Same author

Best practices on blood and blood products for a prehospital hemorrhage protocol: consensus from the 2025 Canadian prehospital transfusion summit.

Scandinavian journal of trauma, resuscitation and emergency medicine·2026
Same author

Preoperative Iron-Deficiency Anemia and Survival After Cardiac Surgery: A Retrospective Cohort Study.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Pediatric transfusion camp: Developing, piloting and evaluation of a Canadian national pediatric transfusion medicine curriculum.

Transfusion·2026
Same author

Rationale, development and feasibility of a national prehospital transfusion registry.

Resuscitation plus·2026
Same author

Association of postoperative haemoglobin with adverse outcomes in patients undergoing cardiac surgery: a retrospective single centre cohort study.

BJA open·2026
Same journal

A Reply to "Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine".

Transfusion medicine reviews·2026
Same journal

Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine.

Transfusion medicine reviews·2026
Same journal

Trust Over Knowledge: Rethinking Donor Iron Supplementation Strategies in Modern Blood Services-Authors' reply.

Transfusion medicine reviews·2026
Same journal

The Effect of Stress Ball and Music on Anxiety, Distress, and Pain Levels During Platelet Apheresis Donation: Randomized Controlled Trial.

Transfusion medicine reviews·2026
Same journal

Therapeutic Plateletpheresis for Thrombocytosis: Critical Analytic Reviews and Original Multicenter Experience.

Transfusion medicine reviews·2026
Same journal

ABO Matching for Platelets: When Surrogates Lead and Clinical Evidence Lags.

Transfusion medicine reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 2, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Transfusion-associated hyperkalemia.

Adrienne Vraets1, Yulia Lin, Jeannie L Callum

  • 1Transfusion Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, Ontario, Canada. adrienne.vraets@utoronto.ca

Transfusion Medicine Reviews
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Elevated potassium in stored red blood cell (RBC) units can cause hyperkalemia. Strategies like washing RBCs and using potassium filters can prevent this transfusion complication.

Related Experiment Videos

Last Updated: Jun 2, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Area of Science:

  • Transfusion Medicine
  • Clinical Biochemistry
  • Hematology

Background:

  • Stored red blood cell (RBC) units exhibit elevated supernatant potassium levels, particularly near expiration.
  • Hyperkalemia is a recognized transfusion complication, with documented cases of cardiac arrest linked to transfusion-associated hyperkalemia.

Purpose of the Study:

  • To review evidence on RBC potassium levels, factors influencing them, clinical impact, and prevention strategies.
  • To consolidate knowledge on transfusion-associated hyperkalemia and its management.

Main Methods:

  • Literature review of studies on RBC potassium concentration, irradiation effects, washing efficacy, and clinical outcomes.
  • Analysis of predictors for post-transfusion hyperkalemia and evaluation of preventative measures.

Main Results:

  • RBC potassium concentration ([K+]) increases linearly with storage duration and is significantly elevated by irradiation.
  • Sufficient potassium exists in RBC units to potentially cause hyperkalemia with large volume transfusions.
  • Post-transfusion hyperkalemia is typically transient due to potassium redistribution.

Conclusions:

  • Transfusion-associated hyperkalemic cardiac arrests are probable, though difficult to definitively prove.
  • RBC washing, in-line potassium filters, and hyperkalemia treatments like insulin are promising preventative strategies.