Related Experiment Video
Updated: Jun 2, 2026
15:48
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
Published on: December 15, 2014
High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions
Hiroyuki Irie1, Noriyuki Kamochi, Junichi Nojiri
1Department of Radiology, Faculty of Medicine, Saga University, Nabeshima, Japan. irie@cc.saga-u.ac.jp
Acta Radiologica (Stockholm, Sweden : 1987)
|April 19, 2011
Summary
High b-value diffusion-weighted MR imaging (DWI) effectively differentiates benign from malignant gallbladder polyps. Malignant lesions show higher signal intensity and lower ADC values than benign ones.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- High b-value diffusion-weighted MR imaging (DWI) is effective in abdominal tumor detection.
- Malignant tumors often exhibit high signal intensity on DWI due to high cellularity or long relaxation times.
- ADC measurement aids in diagnosing abdominal malignancies.
Purpose of the Study:
- To assess the utility of high b-value DWI in distinguishing between benign and malignant polypoid gallbladder lesions.
- Retrospective evaluation of imaging characteristics for improved diagnostic accuracy.
Main Methods:
- Study included 10 benign (hyperplastic polyps, adenomas) and 13 malignant (adenocarcinomas) polypoid gallbladder lesions.
- Lesions were evaluated qualitatively (signal intensity) and quantitatively (ADC values) by two observers.
- Statistical analysis included Fisher's exact test and Mann-Whitney test.
Main Results:
- Qualitative analysis showed a statistically significant difference in signal intensity between benign and malignant lesions (P = 0.0041).
- Malignant lesions exhibited significantly lower ADC values (1.34 ± 0.50 × 10(-3) mm(2)/sec) compared to benign lesions (2.26 ± 0.44 × 10(-3) mm(2)/sec) (P = 0.00016).
- Seven of 13 malignant lesions were very high signal intensity on DWI, while only four of 10 benign lesions were high signal intensity.
Conclusions:
- High b-value DWI, through visual assessment and ADC measurement, shows promise in differentiating benign from malignant polypoid gallbladder lesions.
- This imaging technique can aid in the diagnosis and management of gallbladder polyps.
