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Uric acid levels and atrial fibrillation in hypertensive patients

Tong Liu1, Xiaowei Zhang, Panagiotis Korantzopoulos

  • 1Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, People's Republic of China.

Internal Medicine (Tokyo, Japan)
|April 19, 2011
PubMed

Insights

High uric acid (UA) levels are independently linked to atrial fibrillation (AF) in hypertensive patients. This finding suggests UA may be a significant risk factor for AF in this population.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biochemistry

Background:

  • Uric acid (UA) is recognized as a cardiovascular risk marker linked to oxidative stress and inflammation.
  • Atrial fibrillation (AF) is increasingly associated with inflammatory and oxidative stress pathways.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and the presence of atrial fibrillation in patients with hypertension.

Main Methods:

  • An observational study included 451 hypertensive patients, excluding those with conditions affecting UA metabolism or cardiovascular health.
  • Demographic, clinical, laboratory, and echocardiographic data were collected.
  • Patients were analyzed for the presence of atrial fibrillation (paroxysmal, persistent, or permanent).

Main Results:

  • Univariate analysis revealed higher UA levels, age, hypertension duration, serum creatinine, left atrial diameter (LAD), and ventricular wall thickness in AF patients.
  • Lower estimated glomerular filtration (eGFR) was observed in patients with AF.
  • Multivariate logistic regression identified serum UA (OR: 1.008; 95% CI: 1.003-1.013) and LAD (OR: 1.160; 95% CI: 1.068-1.260) as independent predictors of AF.

Conclusions:

  • This study demonstrates an independent association between elevated serum uric acid levels and atrial fibrillation in hypertensive individuals.
  • Further research in diverse populations is warranted to confirm this association and elucidate underlying pathophysiological mechanisms.
Abstract

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