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Change of transferrin sialylation differs between mild sepsis and severe sepsis and septic shock
Olga Gornik1, Ivan Gornik, Ivana Zagorec Kolednjak
1Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Croatia. ogabela@pharma.hr
Objective And Design:
To investigate the association between the severity of sepsis and changes in sialylation of serum proteins we have conducted a single center pilot study.
Subjects And Methods:
Sialylation of transferrin (with enzyme-linked lectin assay-ELLA) and total serum proteins (with colorimetric assay) as well as serum iron and transferrin levels were measured in 27 patients with sepsis through the first eight days of the disease.
Results:
Total serum sialylation increased in the first two days, transferrin sialylation decreased, while serum iron and transferrin fell. Patients who developed severe sepsis had either a small or marked change in transferrin sialylation while in patients with mild sepsis sialylation decreased moderately.
Conclusion:
We hypothesize that the change in transferrin sialylation could be a reflection of the intensity of inflammatory response which is insufficient if under-expressed and detrimental if over-expressed. This new feature is a potential marker of sepsis severity early in the disease.
