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Lymphatic Vessels and Lymph Transport

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

Development of the Lymphatic System

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Cytotoxic Edema: Pathophysiology

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...

Functions of the Lymphatic and Immune System

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Fluid Connective Tissues: Blood and Lymph

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Blood
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Introduction to Lymphatic and Immune System

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Related Experiment Video

Updated: Jun 2, 2026

A Murine Tail Lymphedema Model

A Murine Tail Lymphedema Model

Published on: February 10, 2021

[Lymphedema].

Satoshi Takakura¹, Izumi Yoshizawa, Masahiro Abo

¹Dept. of Obstetrics and Gynecology, The Jikei University School of Medicine, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|April 19, 2011

Summary

Secondary lymphedema management involves physiotherapy, manual drainage, and compression. Jikei University Hospital implemented the Aggressive Protocol for Patients with LymphedemA Using SophisticatEd methods (APPLAUSE) to address this complication.

Area of Science:

Oncology
Medical Therapeutics
Surgical Complications

Context:

Lymph node dissection is crucial for treating breast cancer and gynecological malignancies.
Secondary lymphedema is a known complication following these procedures.
Effective management strategies are essential for patient recovery and quality of life.

Purpose:

To review established therapies for secondary lymphedema.
To introduce the Aggressive Protocol for Patients with LymphedemA Using SophisticatEd methods (APPLAUSE) implemented at Jikei University Hospital.
To highlight the adoption of the Jikei Lymphedema Assessment Scale (JLA-Se) and LPG technic®.

Summary:

Therapies for secondary lymphedema include complex decongestive physiotherapy, skin care, manual lymphatic drainage, compression bandaging/garments, and limb exercises.

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

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Last Updated: Jun 2, 2026

A Murine Tail Lymphedema Model

A Murine Tail Lymphedema Model

Published on: February 10, 2021

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

Published on: January 12, 2017

The APPLAUSE protocol represents an integrated approach to managing lymphedema.

The JLA-Se and LPG technic® offer standardized assessment and treatment methods.

Impact:

Improved patient outcomes in managing secondary lymphedema.
Enhanced clinical practice through a structured, evidence-based protocol.
Advancement in the assessment and treatment of lymphedema in oncological patients.