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10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Update on the treatment of overactive bladder
Roger R Dmochowski1, Alex Gomelsky
1Department of Urology, Louisiana State University Medical Center, Shreveport, LA, USA. roger.dmochowski@Vanderbilt.edu
Current Opinion in Urology
|April 19, 2011
Summary
Novel treatments for overactive bladder (OAB) show promise. Newer antimuscarinic agents, sacral nerve stimulation, percutaneous tibial nerve stimulation, and botulinum neurotoxin type A offer effective options for OAB symptom management.
Area of Science:
- Urology
- Pharmacology
- Neurology
Background:
- Overactive bladder (OAB) is a common, chronic condition significantly affecting quality of life.
- There is a continuous need for innovative and effective therapeutic strategies for OAB management.
Purpose of the Study:
- To review recent advancements in therapeutic options for overactive bladder (OAB).
- To evaluate the efficacy and safety of novel OAB treatments.
Main Methods:
- Review of recent clinical evidence on antimuscarinic agents, sacral nerve stimulation, percutaneous tibial nerve stimulation, and botulinum neurotoxin type A.
- Analysis of efficacy, safety, and long-term outcomes for various OAB therapies.
Main Results:
- Newer antimuscarinic agents demonstrate superiority over placebo and potential in pediatric and male lower urinary tract symptoms.
- Dose escalation of trospium and fesoterodine is effective and safe, with manageable adverse events.
- Sacral nerve stimulation shows high satisfaction but potential for chronic pain; percutaneous tibial nerve stimulation is well-tolerated with durable outcomes.
- Botulinum neurotoxin type A at 100 U appears optimal for balancing symptom relief and voiding function.
Conclusions:
- Treatment options for OAB are expanding, offering more choices for patients.
- These evolving modalities provide significant benefits for individuals managing overactive bladder symptoms.
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