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Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 2, 2026

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

Stroke induced brain changes: Implications for stem cell transplantation.

Anna Jablonska¹, Barbara Lukomska

¹NeuroRepair Department, Mossakowski Medical Research Center, Polish Academy of Sciences, Warsaw, Poland.

Acta Neurobiologiae Experimentalis

|April 19, 2011

Summary

Ischemic stroke causes significant disability and death, with limited treatments. Understanding stroke

Area of Science:

Neuroscience and Neurology
Cellular and Molecular Biology
Regenerative Medicine

Background:

Ischemic stroke is a leading cause of death and disability worldwide.
Current treatments for established ischemic stroke are limited, and many neuroprotective strategies have failed in clinical trials.
Effective therapeutic interventions require a deeper understanding of the cellular and molecular mechanisms underlying ischemic brain injury.

Purpose of the Study:

To review the current understanding of cellular and molecular processes involved in ischemic stroke pathogenesis.
To identify potential therapeutic targets for neuroprotection and cell recovery following ischemic stroke.
To explore the potential of stem cell transplantation as a therapeutic strategy for stroke disorders.

Main Methods:

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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

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Last Updated: Jun 2, 2026

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Literature review of current research on ischemic stroke biology.
Analysis of cellular and molecular mechanisms, including excitotoxicity, inflammation, neurogenesis, and vascular regeneration.
Evaluation of therapeutic interventions, focusing on neuroprotection and cell recovery.

Main Results:

Key pathological processes in ischemic stroke include excitotoxicity and inflammation.
Endogenous progenitor cells play a role in neurogenesis and vascular regeneration post-stroke.
Therapeutic interventions aim to protect neurons and enhance cell recovery in the ischemic penumbra.

Conclusions:

Understanding the pathogenesis of ischemic stroke is crucial for developing effective treatments.
Targeting excitotoxicity, inflammation, and promoting neurogenesis/vascular regeneration are promising therapeutic avenues.
Stem cell transplantation holds significant promise for treating stroke disorders.