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Updated: Jun 2, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
End-functionalized ROMP polymers for Biomedical Applications
Ahmad E Madkour1, Amelie H R Koch, Karen Lienkamp
1Department of Polymer Science & Engineering, University of Massachusetts, Amherst, MA 01003, USA.
Abstract:
We present two novel allyl-based terminating agents that can be used to end-functionalize living polymer chains obtained by ring-opening metathesis polymerization (ROMP) using Grubbs' third generation catalyst. Both terminating agents can be easily synthesized and yield ROMP polymers with stable, storable activated ester groups at the chain-end. These end-functionalized ROMP polymers are attractive building blocks for advanced polymeric materials, especially in the biomedical field. Dye-labeling and surface-coupling of antimicrobially active polymers using these end-groups were demonstrated.
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