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Related Concept Videos

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...

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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Published on: October 7, 2016

End-functionalized ROMP polymers for Biomedical Applications.

Ahmad E Madkour1, Amelie H R Koch, Karen Lienkamp

  • 1Department of Polymer Science & Engineering, University of Massachusetts, Amherst, MA 01003, USA.

Macromolecules
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Two new allyl-based agents enable stable end-functionalization of ring-opening metathesis polymerization (ROMP) polymers. These activated ester chain-ends are useful for creating advanced materials, particularly in biomedical applications.

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Area of Science:

  • Polymer Chemistry
  • Organic Synthesis
  • Materials Science

Background:

  • Ring-opening metathesis polymerization (ROMP) is a versatile method for polymer synthesis.
  • End-functionalization of polymers is crucial for creating advanced materials.
  • Existing methods for ROMP end-functionalization can be limited in scope or stability.

Purpose of the Study:

  • To develop novel allyl-based terminating agents for ROMP.
  • To achieve stable and storable activated ester groups at the polymer chain-end.
  • To demonstrate the utility of these end-functionalized polymers in advanced applications.

Main Methods:

  • Synthesis of two novel allyl-based terminating agents.
  • End-functionalization of living polymer chains via ROMP using Grubbs' third generation catalyst.
  • Characterization of the resulting polymers and their end-groups.

Main Results:

  • Successful synthesis of two novel terminating agents.
  • Stable, storable activated ester groups were introduced at the chain-end of ROMP polymers.
  • Demonstrated dye-labeling and surface-coupling of polymers with antimicrobial activity.

Conclusions:

  • The developed terminating agents provide a facile route to end-functionalized ROMP polymers.
  • The activated ester end-groups are suitable for further modification and conjugation.
  • These end-functionalized polymers hold significant promise for biomedical materials development.