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Updated: Jun 2, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols
Sandip V Jadhav1, Anupam Bandyopadhyay, Sushil N Benke
1Department of Chemistry, Indian Institute of Science Education and Research, Garware Circle, Pashan, Pune 411021, India.
Abstract:
A facile, efficient and racemization-free method for the synthesis of N-protected β-amino alcohols and peptaibols using N-hydroxysuccinimide active esters is described. Using this method, dipeptide, tripeptide and pentapeptide alcohols were isolated in high yields. The conformations in crystals of β-amino alcohol, dipeptide and tripeptide alcohols were analysed, with a well-defined type III β-turn being observed in the tripeptide alcohol crystals. This method is found to be compatible with Fmoc-, Boc- and other side-chain protecting groups.
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