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Seizures in patients with trisomy 21
1Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
American Journal of Medical Genetics. Supplement
|January 1, 1990
Summary
This study found a higher incidence of seizures, including febrile seizures (FS) and afebrile seizures (aFS), in individuals with Down syndrome (DS). These seizures often manifest early in life, suggesting a link to neurological abnormalities in DS patients.
Area of Science:
- Neurology
- Genetics
- Pediatrics
Background:
- Down syndrome (DS) is associated with various neurological abnormalities.
- Seizure incidence in DS patients requires further investigation.
Purpose of the Study:
- To determine the incidence of seizures in patients with Down syndrome.
- To characterize the types and onset of seizures in this population.
Main Methods:
- Retrospective analysis of 113 patients with Down syndrome.
- Data collected from two research and clinical centers.
Main Results:
- 13.2% of DS patients experienced seizures.
- Febrile seizures (FS) occurred in 5.3%, and afebrile seizures (aFS) in 7.9%.
- Seizures predominantly appeared early in life, with only 2 adult cases.
Conclusions:
- Patients with Down syndrome exhibit a higher incidence of both FS and aFS compared to non-DS individuals.
- Seizures in DS may be a consequence of underlying anatomical and functional neurological differences.
- Early-onset seizures are characteristic in DS patients.