Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Leishmaniasis

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Giardiasis

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Murine leukemia virus resists producer cell APOBEC3A by its Glycosylated Gag but not target cell APOBEC3A.

Virology·2021

Same author

Variation of vital signs with potential to influence the performance of qSOFA scoring in the Ethiopian general population at different altitudes of residency: A multisite cross-sectional study.

PloS one·2021

Same author

Efficiently Restored Thrombopoietin Production by Ashwell-Morell Receptor and IL-6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy.

Hepatology (Baltimore, Md.)·2020

Same author

HIV-2 Vif and foamy virus Bet antagonize APOBEC3B by different mechanisms.

Virology·2020

Same author

Carriage of ESBL-producing Gram-negative bacteria by flies captured in a hospital and its suburban surroundings in Ethiopia.

Antimicrobial resistance and infection control·2020

Same author

Correction to: The role of passive immunization in the age of SARS-CoV-2: an update.

European journal of medical research·2020

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

Published on: April 4, 2025

Mucosal Leishmania infantum infection.

Joachim Richter¹, Ingrid Hanus, Dieter Häussinger

¹Tropical Medicine Unit, Clinics for Gastroenterology, Hepatology and Infectious Diseases, University Clinics Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany. Joachim.Richter@med.uni-duesseldorf.de

Parasitology Research

|April 19, 2011

Summary

Mucosal leishmaniasis caused by Leishmania infantum in Europe is reported. This infection, often relapsing, requires extended treatment and should be considered in differential diagnoses.

More Related Videos

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Published on: July 29, 2021

Related Experiment Videos

Last Updated: Jun 2, 2026

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

Published on: April 4, 2025

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Published on: July 29, 2021

Area of Science:

Infectious Diseases
Parasitology
Dermatology

Background:

Mucosal leishmaniasis is typically associated with Leishmania (Viannia) species in South/Central America.
Leishmania species endemic to the Old World have not been commonly linked to mucosal leishmaniasis.

Purpose of the Study:

To report three cases of mucosal leishmaniasis caused by Leishmania (Leishmania) infantum acquired in Southern Europe.
To highlight the clinical presentation, treatment challenges, and outcomes of these cases.

Main Methods:

Case series reporting on three patients with mucosal leishmaniasis.
Clinical data collection including lesion location, patient immune status, treatment regimens, and outcomes.
Review of treatment response to liposomal amphotericin B and miltefosine.

Main Results:

Three cases of mucosal leishmaniasis caused by Leishmania infantum in Southern Europe were identified.
Lesions occurred in the oral mucosa, esophagus, and nose.
All patients experienced relapses with standard liposomal amphotericin B treatment.
Cure was achieved with secondary, extended treatment using liposomal amphotericin B or miltefosine.
One patient was immunocompetent, while two were immunocompromised.

Conclusions:

Mucosal leishmaniasis due to Leishmania infantum can occur in Southern Europe.
The condition may affect both immunocompromised and immunocompetent individuals.
Relapses are common, necessitating prolonged or alternative treatment strategies.
Consideration of Leishmania infantum in the differential diagnosis of naso-buccal-oesophageal lesions in this region is crucial.