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Updated: Jun 2, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Pericardial effusion and tamponade following interferon alpha treatment for locally advanced melanoma
Jennifer Rauw1, Shaheeda Ahmed, Teresa Petrella
1Internal Medicine, University of Toronto, Toronto, M5G 1V7, Canada.
Abstract:
Regional Metastatic Melanoma has a relatively high mortality rate. Adjuvant interferon-alpha (IFN-α) has been shown to improve disease-free survival, post-resection. Cardiotoxicity associated with IFN-α use has been described previously in the literature, but here we describe the first case of pericardial effusion with cardiac tamponade secondary to IFN-α 2b treatment of melanoma. Clinicians should be aware of this potentially lethal complication and the possible acuity of its onset.
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