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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

Evolving concepts in lung carcinogenesis.

Brigitte N Gomperts1, Avrum Spira, Pierre P Massion

  • 1Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. bgomperts@mednet.ucla.edu

Seminars in Respiratory and Critical Care Medicine
|April 19, 2011
PubMed
Summary
This summary is machine-generated.

Lung cancer development involves genetic mutations and epigenetic changes. Latest research explores inflammation, cancer stem cells, and advanced molecular techniques to find new lung cancer prevention and treatment strategies.

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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung carcinogenesis is a complex, multi-step process.
  • It involves genetic mutations and epigenetic alterations affecting cell functions like proliferation and metastasis.
  • Key factors in initiation include inflammation, field of cancerization, and lung cancer stem cells.

Purpose of the Study:

  • To review current concepts in lung cancer pathogenesis.
  • To highlight the roles of inflammation, field of cancerization, and lung cancer stem cells.
  • To discuss advancements in high-throughput omics technologies for studying lung carcinogenesis.
  • To assess current models and identify future research directions for novel therapies.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of high-throughput genomics, transcriptomics, epigenomics, and proteomics data.
  • Evaluation of in vitro and in vivo models of lung carcinogenesis.

Main Results:

  • Inflammation, field of cancerization, and lung cancer stem cells are crucial in lung cancer initiation.
  • High-throughput omics technologies are significantly advancing the study of lung carcinogenesis.
  • Current models show promise but require further development for comprehensive understanding.

Conclusions:

  • Understanding the complex mechanisms of lung carcinogenesis is key to developing effective strategies.
  • Further research integrating omics data and advanced models is needed.
  • Breakthroughs are anticipated in identifying novel chemoprevention strategies and therapies for lung cancer.