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Related Experiment Video

Updated: Jun 2, 2026

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue
11:31

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Published on: February 11, 2013

Positive visualization of implanted devices with susceptibility gradient mapping using the original resolution.

Gopal Varma1, Rachel E Clough, Peter Acher

  • 1Division of Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, London, United Kingdom. gopal.varma@kcl.ac.uk

Magnetic Resonance in Medicine
|April 19, 2011
PubMed
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A new magnetic resonance imaging technique, SUMO, enhances visualization of small implantable devices. SUMO improves upon susceptibility gradient mapping (SGM) by preserving spatial resolution, aiding in precise imaging of medical implants and cells.

Area of Science:

  • Medical Imaging
  • Biophysics
  • Biomedical Engineering

Background:

  • Implantable devices in MRI typically exhibit negative contrast.
  • Positive contrast techniques like susceptibility gradient mapping (SGM) have been developed.
  • SGM's limitation is reduced spatial resolution, hindering visualization of small structures.

Purpose of the Study:

  • To develop an improved SGM technique (SUMO) that maintains original spatial resolution.
  • To enhance positive contrast visualization of small implantable devices in MRI.
  • To enable quantitative analysis of susceptibility gradients for improved diagnostic information.

Main Methods:

  • A novel filter is applied in k-space within the SGM framework.
  • Signal amplitude is analyzed in the image domain to compute susceptibility gradients per pixel.

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  • The SUMO technique processes data at the original imaging resolution.

    • Main Results:

    • SUMO demonstrates superior visualization of small structures compared to conventional SGM in simulations and experiments.
    • SUMO successfully visualized stents and prostate brachytherapy seeds in patient datasets.
    • The technique quantitatively assessed the number of prostate brachytherapy seeds.

    Conclusions:

    • SUMO offers enhanced positive contrast visualization for small implantable devices in MRI.
    • The method preserves spatial resolution, overcoming a key limitation of SGM.
    • SUMO has potential applications for visualizing other interventional devices and magnetically labeled cells.