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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Diffusion tensor magnetic resonance imaging tractography in progressive supranuclear palsy
Elisa Canu1, Federica Agosta, Francesca Baglio
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy.
Summary
Diffusion tensor imaging tractography reveals significant white matter damage in progressive supranuclear palsy (PSP). This technique accurately maps PSP-related tissue damage in living patients.
Area of Science:
- Neuroimaging
- Neurology
- Biomedical Engineering
Background:
- Diffusion tensor magnetic resonance imaging (DT imaging) tractography enables in vivo quantification of white matter tract integrity.
- White matter abnormalities are implicated in neurodegenerative diseases.
Purpose of the Study:
- To investigate white matter tract damage in progressive supranuclear palsy (PSP) using DT imaging tractography.
- To assess the utility of DT imaging tractography for mapping tissue damage in PSP.
Main Methods:
- DT imaging metrics were acquired from the superior and middle cerebellar peduncles and major cerebral white matter tracts.
- Tractography analysis was performed on 5 patients diagnosed with PSP and 13 healthy controls.
Main Results:
- Patients with PSP exhibited severe intrinsic damage in the superior cerebellar peduncle, corpus callosum, and cingulum.
- Reduced axial diffusivity was specifically observed in the left middle cerebellar peduncle of PSP patients.
Conclusions:
- DT imaging tractography demonstrates potential for precise in vivo cartography of tissue damage in PSP.
- This imaging modality may aid in understanding the neuropathology and progression of PSP.
