Related Experiment Video
Updated: Jun 2, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
[Platelet functions in acute and chronic experimentally induced hepatopathia]
Roxana Irina Iancu1, D Iancu, Doina Murărescu
1Facultatea de Medicină Dentară, Disciplina Patologie Generală, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.
Unlabelled:
It's well known the coagulation damage in chronic hepatitis and hepatic cirrhosis. The aim of our study was to quantify platelet dysfunction in acute and chronic toxic hepatitis.
Material And Method:
We determined adhesivity, aggregability and icosanoids production in rats with acute and chronic hepatopathia induced by CCl4 administration.
Results:
Our data shows that platelet adhesivity and aggregability are affected in chronic toxic affectation but also in acute intoxication (p < 0.05). Icosanoids production (expressed like MDA levels are significantly decreased only in chronic CCl4 intoxication (p < 0.001). Significantly correlation appears between aggregability and adhesivity in control group (r = 0.66) and between aggregability and MDA (r = -0.78) and adhesivity and MDA (r = -0.57) in lot C.
Conclusion:
Primary haemostasis and platelet dysfunction are involved in coagulation dysfunction in hepatic diseases and the modifications of platelet parameters also appeared in acute hepatic affectation.
Related Concept Videos
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Cirrhosis II: Pathophysiology
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
